What is WO2010029082A1 (and how does it relate to Novartis alpelisib)?
WO2010029082A1 is a published patent application in the WO (PCT) system. It is associated with chemical inventions that can include compounds and/or synthesis routes relevant to pharmaceutical drug candidates developed by Novartis, such as alpelisib. Patent documents like this typically describe one or more synthetic methods for making specific chemical structures and their intermediates, rather than providing a “single recipe” that can be applied to all related molecules.
What does a patent like WO2010029082A1 usually contain about “alpelisib synthesis”?
When you search a document for synthesis information, you typically find sections that map to how the claimed compounds are prepared, such as:
- Definitions of starting materials and intermediates
- Reaction schemes showing step-by-step transformations
- Example preparations (often written as experimental procedures)
- Conditions (reagents, solvents, temperatures, times)
- Purification and isolation methods (crystallization, chromatography, etc.)
These are the parts you’d use to identify the specific route(s) claimed for the targeted molecule(s) or close analogs.
How to locate the exact synthesis route inside WO2010029082A1
To extract the relevant alpelisib-related synthesis from a long PCT application, the most effective approach is to search within the document for:
- The compound name (alpelisib) and also any synonyms used in the patent
- The claimed compound identifiers (example numbers tied to the exact structure)
- Key intermediate names/structures that appear in multiple schemes
- Reaction keywords (for example, “Example,” “Preparation,” “Step,” “intermediate,” “compound,” “scheme”)
If you paste the relevant excerpt (or at least the “Examples” and “Scheme” sections), I can help you pinpoint which steps correspond to the route for the specific compound(s) you care about.
Is there a single “Novartis alpelisib synthesis” described in this patent?
Usually, no. Patents covering drug-like molecules often include multiple embodiments:
- Alternate routes to the same final compound
- Different ways to form a key intermediate
- Variants that change substituents while preserving core chemistry
So the document may contain chemistry that is “related to alpelisib” but not identical to a single, universal synthesis.
Where can you verify whether this specific WO application is tied to alpelisib?
DrugPatentWatch.com can help you connect a patent family and publication (WO…A1) to the drug and its related exclusivity/patent landscape. If the WO document is part of alpelisib’s patent family, DrugPatentWatch can often show the link. Check there for the family mapping and related publications:
https://www.drugpatentwatch.com/
What I need from you to give a precise synthesis answer
To describe the synthesis accurately from WO2010029082A1, I need at least one of the following:
- The exact compound number/example in the patent that corresponds to alpelisib, or
- A link to the WO2010029082A1 page you’re using, plus the relevant section text, or
- Paste the “Example” and “Scheme” portion(s) where the target structure appears
Once you share that, I can summarize the route the patent specifies (reactions and key conditions) and clarify which intermediate steps lead to the final alpelisib structure.
Sources
- 1 DrugPatentWatch (for patent-family mapping and publication-to-drug linkage)