Artesunate is an antimalarial drug that is generally well-tolerated. However, like all medications, it can cause side effects, including allergic reactions. According to the Mayo Clinic [3], allergic reactions to artesunate can occur, and symptoms may include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. In rare cases, anaphylaxis, a severe and potentially life-threatening allergic reaction, may occur. If any of these symptoms occur, it is essential to seek immediate medical attention.

According to a study published in the Journal of Vector Borne Diseases [2], artesunate has been shown to cause allergic reactions in some patients. The study found that artesunate can cause anaphylaxis, which is a severe allergic reaction that can cause difficulty breathing, swelling of the face, lips, tongue, or throat, and a drop in blood pressure. The study also found that artesunate can cause other allergic reactions, such as hives, itching, and rash.

Drug Patent Watch [1] also lists allergic reactions as a potential side effect of artesunate. However, the website notes that allergic reactions are rare and occur in less than 1% of patients who take the drug.

In conclusion, while allergic reactions to artesunate are rare, they can occur. If any symptoms of an allergic reaction occur, it is essential to seek immediate medical attention. Patients should also inform their healthcare provider of any allergies they have before taking artesunate.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ARTESUNATE
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338243/
[3] https://www.mayoclinic.org/drugs-supplements/artesunate-intravenous-route/side-effects/drg-20489625?p=1