Cosentyx weight gain or loss?

Does Cosentyx (secukinumab) cause weight gain or weight loss?

Cosentyx is not known for a consistent, direct “weight gain” or “weight loss” effect in the way some drugs are. The most commonly reported issues with Cosentyx are related to infections (because it affects the immune system) and other general side effects, rather than a predictable change in body weight.

What side effects are more likely to affect weight than the drug itself?

If someone taking Cosentyx notices weight change, it’s often from factors other than a direct drug effect, such as:
- Improvement in inflammatory disease activity (for example, fewer symptoms can change appetite and overall activity)
- Intercurrent illness (some infections can cause temporary weight loss)
- Changes in diet, exercise, or other medications used alongside Cosentyx

What should you do if your weight changes on Cosentyx?

If weight change is noticeable or fast, it’s worth talking with the prescribing clinician. They may want to rule out causes like infection or other conditions that can occur while on immune-modulating therapy.

If you share whether the change is gain or loss, roughly how much, and how long it’s been happening, I can help you think through the most likely possibilities to discuss with your doctor.