See the DrugPatentWatch profile for Humira
Does Humira (adalimumab) cause diarrhea?
Yes. Diarrhea is listed as a possible side effect of Humira (adalimumab). It can occur as part of gastrointestinal irritation or as an effect related to the way the immune system is altered by the drug. [1]
What kinds of diarrhea should raise concern?
Seek urgent medical care if diarrhea comes with signs of a serious infection or dehydration, such as:
- fever
- severe or persistent diarrhea
- blood or mucus in the stool
- severe stomach pain
- signs of dehydration (dizziness, very dry mouth, little urine)
Because Humira suppresses parts of the immune response, people taking it can be more vulnerable to infections, and diarrhea can sometimes be a warning symptom. [1][2]
Could Humira-related diarrhea be from an infection?
It can be. Humira can increase the risk of infections, and some infections can cause diarrhea. If diarrhea starts after beginning Humira or worsens while on treatment, clinicians often consider infectious causes (for example, bacterial or other GI infections) alongside medication side effects. [2]
How do patients typically manage mild diarrhea on Humira?
If diarrhea is mild and short-lived, clinicians may recommend supportive care (such as hydration and monitoring symptoms) while deciding whether any evaluation is needed. Because Humira can increase infection risk, persistent symptoms usually warrant contacting a healthcare professional rather than self-managing indefinitely. [2]
When should you contact your doctor about diarrhea while on Humira?
Contact your prescriber promptly if:
- diarrhea lasts more than a couple of days
- symptoms are moderate to severe
- you notice blood in stool or mucus
- you have fever or significant abdominal pain
- you recently started Humira or changed dose and diarrhea began afterward [1][2]
Are there other Humira side effects that patients confuse with diarrhea?
People sometimes report stomach upset alongside diarrhea. Humira can also cause other gastrointestinal complaints (for example, nausea or abdominal discomfort), but the key concern is whether symptoms suggest infection or an allergic reaction. [1]
Sources
[1] U.S. Food and Drug Administration (FDA). Humira (adalimumab) prescribing information (side effects, including diarrhea). https://www.accessdata.fda.gov
[2] U.S. Food and Drug Administration (FDA). Humira (adalimumab) prescribing information (infection warnings/risks). https://www.accessdata.fda.gov