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How does Vascepa differ from standard fish oil supplements? Vascepa contains only purified icosapent ethyl, the ethyl ester of EPA, while fish oil supplements usually contain both EPA and DHA fatty acids. This difference matters because DHA raises LDL cholesterol levels in some patients, whereas Vascepa lowers triglycerides without raising LDL. How much triglyceride lowering does Vascepa provide? Vascepa reduces triglycerides by 20–30% in patients with high levels, especially when taken with diet alone or alongside statins. Clinical data show this effect occurs even in patients whose triglyceride levels are already managed by lifestyle changes. What happens if you take Vascepa and fish oil together? No clinical trials have tested the combination directly. Patients who want additional DHA may add a DHA-only supplement to Vascepa, but doctors usually advise against mixing Vascepa with standard fish oil because doing so could reintroduce the DHA effect on LDL. What side effects are patients reporting when using Vascepa? Bleeding risk increases slightly when Vascepa is used with anticoagulants. Pain in joints, swelling, and constipation are the most common complaints. Many patients report fewer gastrointestinal issues with Vascepa than with standard fish oil. When does Vascepa's patent expire? Vascepa's patent expires in 2030.
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