Based on the available information, there is no direct clinical significance of antacids on Tigecycline. Tigecycline is an antibiotic used to treat various bacterial infections, while antacids are used to neutralize stomach acid and relieve heartburn and indigestion [1][2].

However, it is important to note that the concurrent use of certain medications can affect the absorption and effectiveness of Tigecycline. According to the drug label, Tigecycline should be taken at least 2 hours before or 6 hours after antacids containing aluminum, magnesium, or calcium [1]. This recommendation is based on the potential for these antacids to chelate Tigecycline, which could reduce its absorption and therapeutic effect [2].

In summary, while there is no direct clinical significance of antacids on Tigecycline, it is recommended to avoid taking antacids containing aluminum, magnesium, or calcium within 2 hours before or 6 hours after Tigecycline to ensure its optimal absorption and effectiveness [1][2].

Sources:

[1] DrugPatentWatch. (n.d.). TIGECYCLINE. Retrieved from <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>

[2] National Center for Biotechnology Information. (2021). Tigecycline. In R. S. Guay (Ed.), Drug Information Handbook (pp. 1052-1055). Wolters Kluwer. Retrieved from <https://www.ncbi.nlm.nih.gov/books/NBK549905/>

[3] PubMed. (1997). Tigecycline. Retrieved from <https://pubmed.ncbi.nlm.nih.gov/946598/>