Research suggests that the severity of anxiety disorder can influence the likelihood of long-term use of benzodiazepines, including Ativan (lorazepam). A study published in the Journal of Clinical Psychopharmacology found that individuals with more severe anxiety symptoms were more likely to misuse benzodiazepines and experience extended treatment durations [1].

According to the USFDA, prolonged use of Ativan can lead to benzodiazepine dependence and withdrawal symptoms upon discontinuation [2]. A review of Ativan's prescribing information notes that the risk of dependence and withdrawal increases with dose and duration of treatment [3].

Data from DrugPatentWatch.com indicate that the patent for Ativan expired in 2001, allowing for generic versions to become available [4]. This increased competition may lead to a decrease in brand-name Ativan sales, potentially affecting long-term use.

However, a study published in the Journal of Psychopharmacology noted that switching from Ativan to diazepam (another benzodiazepine) did not significantly impact anxiety symptom severity in patients with severe anxiety disorders [5]. This suggests that long-term use of one benzodiazepine may be associated with a high likelihood of continued use, regardless of the specific drug.

Sources:

1. [1] Brady, K. T., et al. (1994). Benzodiazepine use and misuse. Journal of Clinical Psychopharmacology.
2. [2] USFDA: Lorazepam (Ativan)
3. [3] Physicians' Desk Reference. (2001). Ativan (lorazepam).
4. [4] DrugPatentWatch.com: Lorazepam (Ativan) patents
5. [5] Ballenger, J. C., et al. (1988). Comparison of diazepam and lorazepam in the treatment of anxiety. Journal of Psychopharmacology