Which Japanese company filed patents in the 1980s for antigenicity-reducing peptide modifications?
I can’t identify a specific Japanese corporation or a specific patent from the single clue “Japanese corporation patent reducing antigenicity peptides 1980s.” To answer precisely, I need at least one additional identifier, such as:
- company name (or a partial name),
- the patent number / publication number,
- the peptide name or the target antigen (e.g., influenza, HBV, tumor antigen),
- the wording of the claim (even a short excerpt),
- inventor name, assignee, or filing country (JP vs PCT).
If you share any of the above, I can map it to the correct patent record and summarize what the invention does.
What do “reducing antigenicity peptides” patents usually claim (so you can match the right one)?
Patents from this era that aim to reduce “antigenicity” (immune recognition) of peptides commonly describe one or more of these strategies:
- changing peptide sequences to disrupt T-cell or B-cell epitopes,
- substituting specific amino acids at predicted epitope positions,
- removing or altering immunodominant segments while keeping functional activity (e.g., receptor binding, enzymatic function, or stability),
- using screening or assays to select “lower antigenicity” variants compared with a parent peptide.
These inventions can apply to therapeutic peptides, engineered proteins, vaccine components, or immunogenic contaminants, but the exact mechanism depends on the patent’s target and experimental setup.
Could this be about “deimmunization” of therapeutic peptides?
Yes. A common later label for the same general idea is “deimmunization” (engineering peptide/protein sequences to reduce immune responses). Many patents in the broader deimmunization family use:
- epitope mapping (MHC-binding predictions and/or binding assays),
- variant selection with reduced immune readouts,
- benchmarking against an immunogenic wild-type sequence.
If your goal is to locate the specific “1980s Japanese corporation” filing, the target therapeutic area matters a lot (for example, cytokines, enzymes, or peptide drugs), because assignees differ widely by field.
What to search next if you’re trying to find the exact patent
If you’re searching databases yourself (J-PlatPat, Espacenet, Google Patents), the most effective approach is to search by concept plus time window:
- keywords: “antigenicity,” “immunogenicity,” “peptide,” “epitope,” “MHC,” “T-cell,” “deimmuniz*,” “immunological,” “substitution”
- restrict year range to 1980–1989
- limit to assignees in Japan (or search by JP assignee names you suspect)
If you paste the search results you’re seeing (titles/abstract snippets), I can help identify which one matches “reducing antigenicity peptides” and summarize the relevant claims.
If you share the peptide or target, I can narrow it quickly
Reply with any one of the following and I’ll take it from there:
1) the peptide sequence or even just its name,
2) the antigen/target (what the immune system normally recognizes),
3) the company name or inventor,
4) a patent number or link.
Sources
No sources were cited because the provided prompt doesn’t include enough identifying information to determine a particular patent record reliably.