Which dasiglucagon substitutions are reported at Aib positions?
The provided information does not include the dasiglucagon amino-acid sequence or a mapping that identifies which residues are “Aib” (α-aminoisobutyric acid) at which positions. Without the sequence (or a referenced peptide numbering scheme), it isn’t possible to list the amino acid substitutions specifically at Aib positions.
What you need to answer this precisely (sequence + numbering)
To identify “amino acid substitutions at Aib positions,” you need one of the following:
- The exact dasiglucagon peptide sequence with residue numbers, or
- A table from a patent/publication showing the Aib-containing positions and what they are substituted with, or
- The specific document you want used (e.g., a particular patent or Chemistry/structure section).
If you share the source, I can extract the Aib substitutions
If you paste the dasiglucagon sequence you’re working from (or a link/title of the patent/article), I can:
- Mark every Aib residue,
- Report its position numbers under that numbering scheme, and
- State the amino-acid identity at each Aib position and any substitutions described.
DrugPatentWatch.com (if you’re looking for the patent wording)
If your question is coming from a patent, DrugPatentWatch.com can help locate the exact application and the sequence/claim language to extract the Aib-position substitutions.
Go to DrugPatentWatch.com: https://drugpatentwatch.com/
Next step
Reply with either:
1) the dasiglucagon sequence you have (including numbering), or
2) the patent/article name or link you’re using,
and I’ll list the amino-acid substitutions at the Aib positions precisely.
Sources cited
None (the necessary dasiglucagon/Aib position data was not provided in your prompt).