Is epclusa effective for all genotypes of hepatitis c?

Does Epclusa (sofosbuvir/velpatasvir) work for every hepatitis C genotype?

Epclusa is designed to treat hepatitis C across multiple genotypes, including genotype 1 through genotype 6. It is also used for people with compensated cirrhosis and for certain treatment-experienced groups, depending on the specific regimen and history of prior therapy. [1]

Are any genotypes excluded or need special adjustments?

No hepatitis C genotype is generally excluded from Epclusa’s intended coverage. The key issue in real-world use is usually not “which genotype can it treat,” but whether the person has cirrhosis, prior HCV treatment, HIV coinfection, or other factors that change the full treatment plan. [1]

What about rare variants or mixed genotypes?

If someone has mixed hepatitis C genotypes or unusual viral variants, clinicians typically base treatment on the genotype testing results and resistance-risk considerations. Epclusa’s broad activity is meant to cover the major genotypes, but the exact approach can still depend on lab findings and treatment history. [1]

How effective is it across genotypes?

Across studied groups, Epclusa has shown high cure rates for genotypes 1–6. The evidence basis is broad because the drug was built as a pan-genotypic regimen. [1]

Source

1. https://www.drugs.com/epclusa.html