Based on the information available, there is no evidence to suggest that taking Lipitor (atorvastatin), a medication used to treat high cholesterol, without water will increase its effectiveness. In fact, taking medication with water is generally recommended to ensure proper swallowing and to allow the medication to reach the stomach quickly [1].

The drug's effectiveness is determined by its active ingredient, atorvastatin, which works by blocking an enzyme that contributes to the production of cholesterol in the body [2]. The method of ingestion, such as with or without water, does not affect the drug's interaction with this enzyme.

It is important to follow the instructions provided by a healthcare professional or those listed on the medication label. Any variations from these instructions, such as taking Lipitor without water, should be discussed with a healthcare provider before implementation [3].

In summary, there is no evidence to suggest that taking Lipitor without water will increase its effectiveness. It is recommended to take the medication as directed by a healthcare professional or as indicated on the label.

Sources:
[1] Mayo Clinic. (2021). How to take atorvastatin (Lipitor). <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/proper-use/drg-20064551>.
[2] Drugs.com. (2021). Lipitor. <https://www.drugs.com/lipitor.html>.
[3] DrugPatentWatch.com. (2021). Lipitor (Atorvastatin Calcium). <https://www.drugpatentwatch.com/drugs/lipitor>.