Can tigecycline's liver metabolism cause dosage changes?

Short answer: No. Tigecycline's dosing is not driven by liver metabolism.

Why:
- Tigecycline is not significantly metabolized by the liver. It is eliminated mainly as unchanged drug via biliary/fecal routes.
- Because of this, hepatic impairment generally does not require a dose adjustment. The usual adult dosing (loading 100 mg IV, then 50 mg IV every 12 hours) is used without modification for hepatic impairment in most labeling.

Notes:
- Data in severe hepatic impairment (eg, Child-Pugh C) are limited, but current guidance does not require a routine dose reduction.
- If there are other complicating factors (severe cholestasis, critical illness, drug interactions), consult the prescribing information or a clinician.

If you want, I can pull up the exact labeling language or summarize any specific hepatic impairment scenarios.