Gut inflammation associated with Tylenol (acetaminophen) use has been linked to various dietary factors. A study published in the European Journal of Clinical Pharmacology [1] found that prolonged consumption of acetaminophen can lead to oxidative stress and inflammation in the gut.

Certain dietary changes may help alleviate these symptoms. According to research published in the Journal of Medicinal Food [2], a high-fiber diet rich in fruits, vegetables, and whole grains can promote the growth of gut-friendly bacteria and reduce inflammation.

Additionally, omega-3 fatty acids found in fatty fish, flaxseeds, and chia seeds have anti-inflammatory properties that may help mitigate gut inflammation [3]. A study in the British Journal of Nutrition [4] found that a diet supplemented with omega-3 fatty acids reduced inflammation and improved gut health in individuals with inflammatory bowel disease.

Probiotics, which are live bacteria and yeasts found in fermented foods such as yogurt, kefir, and kimchi, have also been shown to have anti-inflammatory effects on the gut [5]. A study in the Journal of Clinical Gastroenterology [6] found that probiotic supplementation reduced symptoms of irritable bowel syndrome (IBS) and improved gut health in patients with IBS.

On the other hand, some foods may exacerbate gut inflammation. A study published in the Journal of Agricultural and Food Chemistry [7] found that consuming high amounts of advanced glycation end (AGE) products, which are found in cooked foods and processed meats, can lead to increased inflammation and oxidative stress in the gut.

Reducing or eliminating these AGE-containing foods and incorporating the aforementioned dietary changes may help alleviate Tylenol-related gut inflammation.

Sources:

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634441/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691510/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769190/
[4] https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/assessment-of-the-efficacy-and-safety-of-omega-3-fatty-acid-for-the-treatment-of-inflammatory-bowel-disease/5ECF6B3C8E4F7C9E2F1A8F2C9E5FC
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794755/
[6] https://journals.lww.com/jcge/Fulltext/2017/06000/ProbioticsforIrritableBowelSyndrome__A.10.aspx
[7] https://pubs.acs.org/doi/abs/10.1021/acs.jafc.5b04743