Based on the information available, there is no definitive evidence to suggest that oranges can maximize the effectiveness of Lipitor (atorvastatin), a medication used to treat high cholesterol levels. However, a balanced diet, which can include oranges, is generally recommended for overall heart health.

Oranges are a good source of vitamin C and fiber, and they contain hesperidin, a flavonoid with potential cardiovascular benefits [1]. While these nutrients can contribute to heart health, they do not directly interact with Lipitor to increase its effectiveness.

Lipitor works by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol production in the body [2]. The medication's effectiveness is mainly determined by factors such as the correct dosage, individual genetic factors, and adherence to the treatment plan [3][4].

It is always advisable to consult with healthcare professionals, such as a doctor or pharmacist, regarding dietary choices and medication interactions. They can provide personalized advice based on individual health profiles and current medications.

Sources:

1. [Nutrition Data - Orange, Raw, All Varieties](https://nutritiondata.self.com/facts/fruits-and-fruit-juices/1964/2)
2. [Lipitor (Atorvastatin Calcium) Tablets, for Oral Use](https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/20267s123,20268s108,20269s120,21034s115lbl.pdf)
3. [Pharmacogenomics of Statins](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372306/)
4. [Adherence to Statin Therapy in Patients with Atherosclerosis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802336/)

(Note: DrugPatentWatch.com was not used as a source for this answer.)