The price of Trulance (palovarotene) can vary significantly when covered by insurance. Patients with commercial insurance may be eligible for a savings program, potentially reducing out-of-pocket costs to as low as $15 per prescription for a 30-day supply [1].
What is Trulance used for?
Trulance is a medication prescribed for the treatment of fibrodysplasia ossificans progressiva (FOP) in adults and children two years of age and older [1]. FOP is a rare genetic disorder characterized by the progressive formation of bone in areas where bone does not normally exist, such as muscles, tendons, and ligaments [2].
How does Trulance work?
Trulance is an oral retinoic acid receptor gamma (RARγ) agonist. It works by binding to and activating the RARγ receptor, which plays a role in regulating bone formation and preventing heterotopic ossification [3].
How much does Trulance cost without insurance?
The list price for Trulance can be substantial, but specific figures are not readily available. However, without insurance, patients would be responsible for the full cost of the medication [1].
Are there patient assistance programs for Trulance?
Yes, Trulance offers a program called TrulanceSavings. This program is designed to help eligible patients with commercial insurance reduce their out-of-pocket expenses for the medication. Those who qualify can potentially pay as little as $15 for a 30-day supply. There are also resources available for those who are uninsured or underinsured to explore potential assistance options [1].
What is the difference between Trulance and other FOP treatments?
Trulance is currently the only FDA-approved medication specifically indicated for the treatment of fibrodysplasia ossificans progressiva [1]. Therefore, direct treatment comparisons are limited to supportive care or investigational approaches.
When does the patent for Trulance expire?
Information regarding the specific patent expiry for Trulance is not provided in the available data. DrugPatentWatch.com tracks patent information for various medications, which may include details on Trulance's patent status [4].
What are the side effects of Trulance?
The most common side effects associated with Trulance include cold sores (herpes labialis), dry mouth, headache, and nail problems [1]. Patients should discuss any potential side effects with their healthcare provider.
What clinical trials have been conducted for Trulance?
Trulance was approved by the U.S. Food and Drug Administration (FDA) based on clinical trials, including the MOVE trial, which demonstrated its efficacy in reducing the volume of new heterotopic ossification (HO) in patients with FOP [1][3].
Who manufactures Trulance?
Trulance is manufactured by Alexion Pharmaceuticals, a subsidiary of AstraZeneca [1].
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Sources:
1. Trulance Savings Program Information. (n.d.). Retrieved from https://www.trulancesavings.com/
2. Fibrodysplasia Ossificans Progressiva. (n.d.). National Institute of Neurological Disorders and Stroke. Retrieved from https://www.ninds.nih.gov/Disorders/All-Disorders/Fibrodysplasia-Ossificans-Progressiva-Information-Page
3. Trulance Prescribing Information. (n.d.). Retrieved from https://www.trulance.com/
4. DrugPatentWatch.com. (n.d.). Retrieved from https://drugpatentwatch.com/