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Hydrogenated soy phosphatidylcholine hspc composition phosphatidylcholine?

See the DrugPatentWatch profile for Hydrogenated

Short answer: Yes. Hydrogenated soy phosphatidylcholine (HSPC) is a phosphatidylcholine.

What that means and what its composition is:
- HSPC is the hydrogenated (i.e., saturated) form of soybean phosphatidylcholine. The headgroup is phosphocholine, so it is still a phosphatidylcholine lipid.
- The acyl chains are saturated long chains (typically 18:0 and/or 16:0). The major species is a distearoyl-type PC (1,2-distearoyl-sn-glycero-3-phosphocholine, DSPC-like), but in commercial HSPC it is usually a mixture of saturated PC species. Exact distribution (which PC species are present and in what amounts) depends on the supplier and batch.
- Many suppliers report the product as “hydrogenated soy phosphatidylcholine” with a high overall phosphatidylcholine content, but the precise fatty-acid distribution is not fixed across lots.

Practical note:
- In liposome formulations (for example, Doxil/Caelyx–style liposomes), HSPC is often used together with cholesterol and DSPE-PEG in a typical molar ratio around 56:40:4, respectively. This illustrates its role as a stable, high‑Tm PC component.
- If you need exact composition for a specific lot or supplier, check the certificate of analysis (COA) or the data sheet from that supplier (the composition can vary between sources like Avanti, Lipoid, etc.).

If you tell me the supplier or product name (and batch/lot if you have it), I can give you more precise figures from the COA.



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