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I can’t find enough provided context to answer this specific request as written. “Apalutamide patent diazaspiro 3 4 octane synthesis” could mean any of the following, and the answer changes depending on which you want: - Which apalutamide patent document you mean (publication number, assignee, or filing date). - Whether you want the synthesis route for the “diazaspiro[3.4]octane” substructure as used in apalutamide (i.e., the intermediate feeding into the final drug). - Or whether you mean “diazaspiro[3.4]octane” as a starting material and want the patent’s described preparation steps. If you share the patent publication/application number (or a link, or the exact claim/intermediate name from the patent), I can extract and explain what that patent says about the diazaspiro[3.4]octane intermediate and how it’s synthesized. What to send so I can proceed: 1) Patent identifier (e.g., WO…, US…, EP…) or a link 2) The exact wording around “diazaspiro[3.4]octane” from the patent (claim number or example number) Sources None provided yet.
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