What side effects does Trintellix (vortioxetine) cause?
Common side effects reported with Trintellix (vortioxetine) tend to be gastrointestinal and central nervous system-related. These include nausea, constipation, diarrhea, vomiting, dizziness, and sleepiness or fatigue. [1]
How common is nausea, and what helps?
Nausea is the most frequently reported Trintellix side effect and can be dose-related. If nausea is an issue, clinicians often adjust the dose or timing and may recommend taking the medication with food (or ensuring it’s taken consistently the same way each day). If nausea is severe or persists, speak with the prescriber rather than stopping on your own. [1]
What are the serious side effects to watch for?
Like other antidepressants, Trintellix carries warnings that patients and clinicians monitor for, including worsening depression or unusual changes in mood and behavior, and symptoms that could indicate serotonin-related effects. Seek urgent medical care for severe reactions or rapidly worsening symptoms. [1]
Does Trintellix affect sexual function?
Trintellix can cause sexual side effects, which are a known concern with many antidepressants. If you notice changes in libido, arousal, or orgasm, bring them up with your prescriber; dose adjustments or switching treatments can sometimes help. [1]
Are there differences by age, dose, or who takes it with other meds?
Side effect likelihood can vary by dose and by patient factors such as age and overall health. Drug interactions can also increase the risk of certain adverse effects; it’s important to tell your clinician about all medications, supplements, and alcohol use when starting or changing Trintellix. [1]
When should you call a doctor about Trintellix?
Contact a clinician promptly for troubling side effects such as persistent vomiting, dehydration signs, severe dizziness, fainting, agitation, confusion, or any symptoms that feel unusual compared with your baseline. For emergencies (for example, severe allergic symptoms or severe serotonin-related symptoms), seek emergency care. [1]
What side effects do people compare against other antidepressants?
People often compare Trintellix with SSRIs and other antidepressants in terms of nausea and sexual side effects, since different meds can shift which side effects are most noticeable. If you’re choosing between options, your prescriber can weigh your symptom profile (for example, whether nausea or sexual side effects would be most problematic) and your medical history. [1]
Source
[1] https://www.drugs.com/sfx/trintellix-side-effects.html