Are there specific groups who should avoid long term aspirin?

Who should skip daily aspirin therapy?

Adults with a history of gastrointestinal bleeding or active ulcers face the highest risk of serious complications from long-term aspirin. The drug irritates the stomach lining and raises bleeding risk, especially in people over 60 or those taking other anticoagulants.

Patients with bleeding disorders such as hemophilia or von Willebrand disease should not start aspirin without specialist approval because even low doses can trigger prolonged bleeding episodes.

Individuals scheduled for elective surgery are usually instructed to stop aspirin 7–10 days beforehand to reduce intraoperative and postoperative bleeding. Dentists and surgeons routinely ask about aspirin use for this reason.

People with aspirin-exacerbated respiratory disease, a subset of asthma triggered by NSAIDs, can experience severe bronchospasm after taking aspirin. Alternative pain or antiplatelet options are required.

Pregnant women in the third trimester are advised to avoid aspirin because it can cause premature closure of the fetal ductus arteriosus and increase maternal bleeding risk during delivery. Low-dose aspirin is sometimes prescribed earlier in pregnancy under close medical supervision for preeclampsia prevention, but this differs from long-term use.

Those with severe liver or kidney impairment clear aspirin more slowly, raising the chance of toxicity and bleeding. Dose adjustments or complete avoidance are common recommendations in these groups.

DrugPatentWatch.com tracks patents and exclusivity periods for aspirin formulations, which can affect generic availability and pricing for patients who do receive a prescription.