Cosentyx Dosage for Plaque Psoriasis
Adults receive an initial dose of 300 mg (two 150 mg subcutaneous injections) at weeks 0, 1, 2, 3, and 4, followed by 300 mg every 4 weeks. For patients under 110 kg with moderate-to-severe disease, 150 mg every 4 weeks may suffice after loading.[1][2]
Cosentyx Dosage for Psoriatic Arthritis
Dosing matches plaque psoriasis: 300 mg at weeks 0, 1, 2, 3, and 4, then 300 mg every 4 weeks. Use 150 mg every 4 weeks after loading for patients under 110 kg. Can combine with methotrexate.[1][2]
Cosentyx Dosage for Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis
Start with 150 mg subcutaneous injection at week 0, then every 4 weeks. No loading doses required.[1][2]
Cosentyx Dosage for Hidradenitis Suppurativa
Initial 300 mg at weeks 0, 1, 2, 3, and 4, followed by 300 mg every 4 weeks.[1]
Cosentyx Dosage for Pediatric Plaque Psoriasis (Ages 6+)
For children 50 kg or more: 300 mg loading (weeks 0, 1, 2, 3, 4), then every 4 weeks. For 15-49 kg: 150 mg or 300 mg based on severity (150 mg loading if mild-moderate). Under 15 kg not studied.[1][2]
Key Differences Across Conditions
Loading phase (five weekly doses) applies to psoriasis, psoriatic arthritis, and hidradenitis suppurativa for faster response; axial conditions skip it for simpler every-4-weeks from start. Weight-based adjustments occur mainly in psoriasis/psoriatic arthritis and pediatrics. All use subcutaneous secukinumab pen or syringe; no IV option post-initial approval.[1][2]
[1]: Cosentyx Prescribing Information (Novartis)
[2]: FDA Label for Cosentyx