Advil, a popular over-the-counter pain reliever, has evolved significantly since its invention. Advil's active ingredient, ibuprofen, was discovered in the 1960s and was first approved for use in the United States in 1974 [1]. Advil was first introduced in 1984 as a prescription medication, but it was approved for over-the-counter use in 1985 [2].

Since its introduction, Advil has undergone several changes and improvements. In 1994, Advil introduced a new formulation called Advil Liqui-Gels, which contains a liquid center that allows for faster absorption of the medication [3]. In 1996, Advil added a new product to its line, Advil Migraine, which is specifically formulated to relieve migraine headaches [3].

In recent years, Advil has continued to innovate and expand its product line. In 2009, Advil introduced Advil PM, which combines ibuprofen with the sleep aid diphenhydramine to provide relief for pain and sleeplessness [3]. In 2016, Advil launched Advil Dual Action, which combines ibuprofen with acetaminophen to provide dual relief for pain [3].

Despite its success, Advil has faced challenges over the years. In 1982, the Tylenol murders, in which several people died after taking cyanide-laced Tylenol capsules, led to increased scrutiny of over-the-counter medications [2]. In response, Advil and other manufacturers introduced tamper-resistant packaging to prevent contamination [2].

In conclusion, Advil has evolved significantly since its introduction in 1984. It has undergone several changes and improvements, including new formulations and products. Advil has also faced challenges, such as increased scrutiny of over-the-counter medications after the Tylenol murders. However, Advil has continued to innovate and expand its product line to provide relief for pain and other symptoms.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.pbs.org/newshour/health/tylenol-murders-1982
[3] https://www.advil.com/advil-story/