Based on the information available, it is possible to substitute generic alprazolam, the active ingredient in Xanax, for the brand name medication in many cases. The U.S. Food and Drug Administration (FDA) requires that generic drugs have the same active ingredient, strength, dosage form, and route of administration as the brand name drug. They must also be shown to be therapeutically equivalent, meaning they should work in the body in the same way and have the same clinical effect as the brand name drug [1].

However, there are a few important considerations to keep in mind when substituting generic alprazolam for Xanax. First, while the active ingredient is the same, other inactive ingredients may differ between the brand name and generic versions. These inactive ingredients, such as binders, coatings, and fillers, may cause allergic reactions or other adverse effects in some people [2].

Additionally, it is important to note that while generic drugs must be shown to be therapeutically equivalent to brand name drugs, they may not be exact copies of the brand name drug in terms of how they are absorbed and metabolized in the body. This can lead to differences in how quickly the drug takes effect and how long it stays in the body [3].

It is always recommended to consult with a healthcare provider before switching from a brand name drug to a generic version or vice versa. They can help determine whether a generic substitute is appropriate based on individual factors such as medical history, current medications, and potential drug interactions.

Sources:

1. U.S. Food and Drug Administration. (2021). Generic Drugs: Questions and Answers. <https://www.fda.gov/drugs/understanding-generic-drugs/generic-drugs-questions-and-answers>
2. Mayo Clinic. (2020). Generic drugs: Same safety, effectiveness as brand-name drugs. <https://www.mayoclinic.org/diseases-conditions/drug-safety/in-depth/generic-drugs/art-20046385>
3. U.S. Food and Drug Administration. (2021). Bioequivalence Studies for Generic Drugs. <https://www.fda.gov/drugs/development-approval-process-drugs/bioequivalence-studies-generic-drugs>
4. DrugPatentWatch. (2021). Xanax (alprazolam) Patent Expiration & Generic Entry. <https://www.drugpatentwatch.com/patent/xanax-alprazolam-patent-expiration-generic-entry/>