How to Use Otrexup Auto-Injector for Arthritis
Otrexup delivers methotrexate, a weekly injection for rheumatoid arthritis to reduce joint inflammation. Use it once weekly on the same day, exactly as your doctor prescribes—typically 7.5 mg to 25 mg based on your dose.[1] Do not take extra doses or use daily.
Step-by-Step Injection Instructions
1. Prepare: Wash hands. Find a clean, flat surface. Check expiration date and inspect the device—no cracks or leaks. Remove from refrigerator 30 minutes before use to reach room temperature; do not shake.[1]
2. Choose site: Use abdomen (2 inches from navel), upper outer thigh, or outer upper arm (with help). Avoid scars, bruises, or tender areas. Rotate sites weekly.[1]
3. Clean and position: Wipe site with alcohol swab; let dry. Remove orange cap by pulling straight off—do not twist. Hold injector with gray top up, like a syringe.[1]
4. Inject: Place black tip firmly against skin at 90-degree angle. Press gray top fully down—you'll hear a click and feel it push. Hold steady for 5 full seconds (count slowly); needle retracts automatically. A click or "pop" confirms completion.[1]
5. Finish: Dispose injector in sharps container. If no click or incomplete dose, call your doctor—do not reuse.
Administer at home after training from your healthcare provider. Full instructions come with each device.[1]
What If Something Goes Wrong During Use?
- No click or needle doesn't deploy: Press gray top harder or restart with new device.
- Bleeding or pain: Apply pressure; mild redness is normal.
- Missed dose: Take as soon as remembered if within 2 days; otherwise skip and resume schedule. Do not double up.[1]
- Device damaged: Use a new one; contact pharmacy.
Common Side Effects and Precautions for Arthritis Patients
Nausea, fatigue, mouth sores, or hair thinning occur in many users—take folic acid supplement as prescribed to ease them. Monitor for serious issues like liver problems, low blood counts, or infections; get blood tests monthly.[2] Avoid alcohol, live vaccines, and NSAIDs without doctor approval. Pregnancy risk—use birth control.[1][2]
Dosage and Storage Tips
Starts at 7.5 mg weekly, up to 25 mg max. Store in fridge (36-46°F); okay at room temperature up to 7 days. Keep away from kids and light.[1]
Where to Get Training and Supplies
Your rheumatologist or pharmacy demonstrates first use. Otrexup kits include extras like alcohol swabs. Antares Pharma manufactures; check insurance for copay cards.[1]
[1]: Otrexup Prescribing Information
[2]: Drugs.com - Otrexup