Lacosamide is an anticonvulsant medication that is used to treat partial-onset seizures in adults and children who are four years of age or older. According to the FDA label [2], lacosamide is contraindicated in patients with known hypersensitivity to the drug or its ingredients. It is also not recommended for patients with second- or third-degree atrioventricular (AV) block, or those with a history of cardiac conduction problems. Lacosamide should be used with caution in patients with a history of cardiac disease, and ECG monitoring is recommended in such patients. A study published in the journal Epilepsy Research and Treatment [3] found that lacosamide may be associated with a slight increase in the risk of cardiac adverse events, such as QT prolongation and bradycardia, especially in patients with pre-existing cardiac conditions. Therefore, it is important for healthcare providers to carefully evaluate the risks and benefits of lacosamide treatment in patients with cardiovascular conditions, and to monitor patients closely for any signs of cardiac adverse events.

Sources:
[2] FDA Label for Lacosamide: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/022253s042lbl.pdf
[3] Epilepsy Research and Treatment: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862116/