Standard Dosing Schedule for Skyrizi in Psoriasis
Skyrizi (risankizumab) is injected subcutaneously for plaque psoriasis. The regimen starts with two 150 mg starter doses, given 4 weeks apart (weeks 0 and 4). After that, patients receive one 150 mg maintenance dose every 12 weeks.[1]
How Patients Administer It at Home
Once trained by a healthcare provider, adults self-inject using prefilled syringes or autoinjectors (150 mg/mL). Each dose is one injection into the thigh or abdomen; arms can be used with help. Sites rotate to avoid irritation.[1]
What If You Miss a Dose?
Take the missed dose as soon as possible, then resume the original schedule. If it's near the next dose (within a few days), skip it and proceed—no double-dosing.[1]
Differences from Other Psoriasis Biologics
Skyrizi's every-12-week maintenance is less frequent than many competitors:
| Drug | Maintenance Frequency |
|------|-----------------------|
| Skyrizi | Every 12 weeks |
| Tremfya (guselkumab) | Every 8 weeks |
| Cosentyx (secukinumab) | Every 4 weeks |
| Stelara (ustekinumab) | Every 12 weeks (weight-based) |
| Taltz (ixekizumab) | Every 4 weeks |
This suits patients seeking fewer injections.[1][2]
Who Should Avoid or Adjust Skyrizi
Active infections delay starting. No dose changes for mild liver/kidney issues, but monitor closely. Not approved for kids under 18 or pregnant/nursing patients (limited data).[1]
Injection Site Reactions and Tips
Common: redness, pain, or itching at the site (affects ~10-20% initially, fades). Use room-temperature drug, clean skin with alcohol, and apply ice post-injection if needed.[1]
[1]: Skyrizi Prescribing Information (AbbVie)
[2]: Drugs.com - Skyrizi Dosing