There are US patent applications and issued US patents related to biosynthesis/chemoenzymatic synthesis of heparin and heparan sulfate. The work generally focuses on producing non-animal, defined heparin-like molecules using enzymes (sulfotransferases, glycosyltransferases, etc.) or recombinant/chemoenzymatic routes, rather than extracting from animal tissues. This area is sometimes described as “chemoenzymatic synthesis of heparin/heparan sulfate” or “biosynthesis of heparin.”
If you’d like, I can pull together a current list with US patent application numbers, titles, inventors, assignees, and status (pending/issued, prosecution status). To keep it accurate, I’ll need to search up-to-date patent databases.
A few tips to search yourself (good starting points):
- Databases: USPTO PatentsView / Patent Center, Google Patents, Espacenet.
- Keywords: “heparin biosynthesis,” “chemoenzymatic synthesis of heparin,” “heparan sulfate synthesis,” “recombinant heparin,” “glycosaminoglycan biosynthesis,” “NDST,” “3-O-sulfotransferase,” “heparosan,” “chemoenzymatic heparan sulfate.”
- Look for assignees like Rutgers University (Linhardt group) and other academic or biotech entities known for GAG research.
- Filter for US publications/applications and then check the current status (granted vs. pending).
Would you like me to search now and summarize the US patent landscape on biosynthesis of heparin with specific patent numbers, titles, inventors, assignees, and status? If so, tell me whether you want only US documents or also other jurisdictions, and whether you want a quick summary or a more detailed table.