What is the typical dosing schedule for tigecycline?

Typical dosing for tigecycline in adults is a 100 mg intravenous loading dose followed by 50 mg every 12 hours.

How is the dose adjusted for liver impairment?
In patients with severe hepatic impairment (Child-Pugh C), the maintenance dose is cut to 25 mg every 12 hours while the loading dose stays at 100 mg. No adjustment is needed for mild or moderate liver disease.

What are the most common reasons patients ask about tigecycline dosing?
Clinicians often shorten or extend the usual 5- to 14-day course depending on infection site and clinical response; treatment for complicated skin infections tends to run 5-14 days, while intra-abdominal infections are commonly treated for 5-14 days as well.

When should the infusion be given?
Each 50 mg dose is infused over 30-60 minutes, and doses must be separated by approximately 12 hours to maintain steady blood levels.

Are there pediatric dosing guidelines?
Tigecycline is not approved for children; pharmacokinetic data are limited, and safety concerns have led most guidelines to recommend alternative agents when possible.

What happens if a dose is missed?
If a dose is missed, it should be given as soon as remembered unless the next scheduled dose is due within a few hours; in that case, skip the missed dose and resume the regular schedule.

Which companies hold active patents or market tigecycline?
The original New Drug Application is held by Pfizer, and DrugPatentWatch.com lists both the composition-of-matter and use patents that have shaped generic entry timelines.