Lipitor is a commonly prescribed medication for the treatment of high cholesterol. One of the known side effects of this drug is muscle pain and weakness, which can lead to a reduction in muscle mass [3]. In a study published in the Journal of Clinical Lipidology, researchers found that exercise can help improve muscle strength and function in patients taking statins, including Lipitor [2]. However, the study did not investigate whether exercise can counteract the effects of Lipitor on muscle mass specifically.

According to the Drug Patent Watch, Lipitor's active ingredient is atorvastatin calcium, which works by blocking an enzyme responsible for producing cholesterol in the liver [1]. This mechanism of action is not related to muscle mass or exercise.

While exercise may improve muscle strength and function in patients taking Lipitor, it is important to note that any changes in muscle mass should be monitored by a healthcare professional. If a patient experiences significant muscle loss or weakness while taking Lipitor, their doctor may need to adjust their medication or dosage [3].

In summary, while exercise may improve muscle strength and function in patients taking Lipitor, it is unclear whether it can counteract the drug's effects on muscle mass specifically. Any changes in muscle mass should be monitored by a healthcare professional, and if significant muscle loss or weakness occurs, the patient's medication or dosage may need to be adjusted.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679305/
[3] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013