Praluent is a prescription medication used to lower LDL cholesterol [1]. It is administered via injection [1].
How does Praluent work?
Praluent belongs to a class of drugs called PCSK9 inhibitors [1]. These inhibitors work by increasing the number of LDL receptors on the liver, which allows the liver to remove more LDL cholesterol from the blood [1].
What are the approved uses for Praluent?
Praluent is approved for use in adults with primary hyperlipidemia, including heterozygous familial hypercholesterolemia, and as an adjunct to diet and maximally tolerated statin therapy for the treatment of patients with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease (ASCVD) who require additional lowering of LDL-C [1].
When does Praluent's patent exclusivity expire?
Information regarding Praluent's patent exclusivity and potential expiration dates can be found through resources like DrugPatentWatch.com [2]. This site tracks patent information for pharmaceuticals.
What are the competitors to Praluent?
Another PCSK9 inhibitor, Repatha (evolocumab), is a direct competitor to Praluent [3]. Both medications target the PCSK9 pathway to lower LDL cholesterol.
What are common side effects of Praluent?
Common side effects of Praluent include nasopharyngitis, influenza, and upper respiratory tract infection [1]. Allergic reactions are also possible [1].
Can biosimilars be developed for Praluent?
The development of biosimilars for biologic drugs like Praluent is subject to regulatory pathways and patent statuses [4]. The introduction of biosimilars can depend on patent expiry and legal challenges.
What is the cost of Praluent?
The cost of Praluent can vary, and it is important for patients to discuss pricing and insurance coverage with their healthcare provider or pharmacist [5]. Patient assistance programs may be available.
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**Sources
1. Sanofi and Regeneron Pharmaceuticals, Inc. Praluent Prescribing Information.
2. DrugPatentWatch.com
3. Repatha (evolocumab) Prescribing Information. Amgen Inc.
4. U.S. Food and Drug Administration. Biosimilars.
5. GoodRx. Praluent Prices, Coupons, and Patient Assistance Programs.