What's the frequency of severe diarrhea with tigecycline?

Severe diarrhea is uncommon with tigecycline.

- Grade 3–4 (severe) diarrhea: about 1% or less of patients in pivotal trials (roughly in the low single digits).
- Any diarrhea: generally reported in the range of about 10–15% of patients.
- There have been rare cases of Clostridioides difficile–associated diarrhea.

If you’d like, I can pull the exact current labeling numbers for your region or a specific indication. And if you or someone you care for is having severe diarrhea, especially with fever, dehydration, or blood in stool, seek medical care promptly.