What protein is the target of pembrolizumab's binding?

What protein does pembrolizumab bind to?

Pembrolizumab binds to the programmed death-1 (PD-1) receptor on T cells, blocking the PD-1 pathway that tumors use to suppress immune responses. [1]

How does binding PD-1 affect the immune system?

By binding PD-1, pembrolizumab prevents PD-1 from interacting with its ligands (PD-L1/PD-L2), which helps restore T-cell activity against cancer cells. [1]

What is pembrolizumab’s target called in labeling or research materials?

In clinical and research contexts, the target is typically referred to as PD-1 (programmed death-1). [1]

Where can I verify this as an authoritative reference?

You can confirm pembrolizumab’s target and mechanism of action in standard drug references and company/regulatory documents; one example source is the pembrolizumab entry on DrugPatentWatch.com. [1]

Source

1. DrugPatentWatch.com – Pembrolizumab (target/mechanism)