How does naproxen compare to aspirin for pain relief?
Naproxen and aspirin both relieve mild to moderate pain, inflammation, and fever as nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen lasts longer—up to 12 hours per dose—while aspirin acts faster but requires more frequent dosing, every 4-6 hours. Naproxen suits chronic conditions like arthritis; aspirin works better for acute headaches or muscle aches.[1][2]
When to pick naproxen over aspirin?
Choose naproxen for extended relief without redosing, such as back pain or menstrual cramps. It's less likely to cause stomach upset at equivalent doses due to slower absorption. Avoid naproxen if you need aspirin's blood-thinning effect for heart attack prevention—aspirin inhibits platelets longer-term, while naproxen does not.[3][4]
Key side effect differences
Both risk stomach ulcers, bleeding, and kidney issues with long-term use. Aspirin raises tinnitus risk more; naproxen links to higher heart attack or stroke odds in some studies, especially at high doses over months. Naproxen may cause more drowsiness. Limit both to short-term use unless prescribed.[2][5]
Can you switch from aspirin to naproxen safely?
Yes, for pain alone, but not for cardiovascular protection—aspirin reduces clot risk, naproxen does not and might interfere. Consult a doctor if on blood thinners or with ulcers, heart disease, or pregnancy. Start with lowest effective dose: naproxen 220-500mg every 12 hours, aspirin 325-650mg every 4-6 hours.[1][4]
Dosage and availability
Over-the-counter naproxen (Aleve) starts at 220mg; prescription up to 1,500mg daily. Aspirin (Bayer) is cheaper at 81-325mg doses. No generics issue—both off-patent since the 1970s.[6]
[1] FDA Drug Label: Naproxen (https://www.accessdata.fda.gov/drugsatfdadocs/label/2016/018482s097lbl.pdf)
[2] FDA Drug Label: Aspirin (https://www.accessdata.fda.gov/drugsatfdadocs/label/2009/080136s092lbl.pdf)
[3] Mayo Clinic: NSAIDs Comparison (https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/pain-relievers/art-20046858)
[4] American Heart Association: Aspirin vs NSAIDs (https://www.heart.org/en/health-topics/heart-attack/treatment-of-a-heart-attack/aspirin-and-heart-disease)
[5] NIH: NSAID Risks (https://www.nccih.nih.gov/health/pain-herbs-spices-and-supplements)
[6] Drugs.com: Naproxen vs Aspirin (https://www.drugs.com/compare/aspirin-vs-naproxen)