Probenecid is a medication that affects the kidneys' ability to eliminate certain drugs, which can impact their bioavailability. When co-administered with tigecycline [1](https://www.drugpatentwatch.com/rx/US-20060213329/ US6048799), a broad-spectrum antibiotic, probenecid does not significantly affect tigecycline's bioavailability [2]([3]https://www.drugpatentwatch.com/rx/US-20100041039/ US 20100041039).

According to studies, co-administration of probenecid with tigecycline may actually increase the maximum concentration of tigecycline in the body [1]([4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444446/). Probenecid's impact is due to its ability to inhibit the organic anion transporting polypeptide (OAT) 1 5, which is involved in the transport of tigecycline in the kidneys [2].

The interaction between probenecid and tigecycline may be relevant for patients receiving these medications concomitantly, as it can affect tigecycline's efficacy and duration of action.

Sources:

1. [${1}] - https://www.drugpatentwatch.com/rx/US-20060213329/ US6048799
2. [${2}] - https://www.drugpatentwatch.com/rx/US-20100041039/ US 20100041039
3. [${4}] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444446/
4. [${5}] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444446/