See the DrugPatentWatch profile for prednisone
Common Side Effects of Prednisone
Prednisone, a corticosteroid, often causes short-term effects like increased appetite, weight gain, insomnia, mood changes (irritability or anxiety), indigestion, and elevated blood sugar. These typically appear within days of starting and improve after stopping.[1][2]
Serious Long-Term Side Effects
Prolonged use (weeks to months) raises risks of osteoporosis (bone thinning and fractures), high blood pressure, cataracts, glaucoma, muscle weakness, thinning skin with easy bruising, and suppressed adrenal gland function, which can lead to adrenal crisis if stopped abruptly.[1][3]
Side Effects in Children
Kids on prednisone may experience growth suppression, delayed puberty, and behavioral changes like hyperactivity. Doses are kept lowest possible to minimize these.[2][4]
What Happens with High Doses or Abrupt Stopping?
High doses amplify risks like stomach ulcers, fluid retention, and psychosis. Sudden discontinuation causes withdrawal symptoms: fatigue, joint pain, nausea, and low blood pressure from adrenal insufficiency. Taper gradually under medical supervision.[1][3]
Side Effects by Duration of Use
- Short-term (under 2 weeks): Mostly mild, like nausea or headache.
- Medium-term (2-4 weeks): Adds acne, facial swelling (moon face), and buffalo hump.
- Long-term (months+): Increases infection risk due to immune suppression, diabetes, and heart disease.[2][4]
Managing Prednisone Side Effects
Doctors recommend calcium/vitamin D supplements for bones, blood pressure checks, eye exams, and lowest effective doses. Lifestyle steps include diet control for weight and sugar, stress reduction for mood, and infection precautions.[1][3]
Sources
[1]: Mayo Clinic - Prednisone Side Effects
[2]: Drugs.com - Prednisone Side Effects
[3]: MedlinePlus - Prednisone
[4]: Cleveland Clinic - Prednisone