Lipitor is a brand name for atorvastatin, which is a medication used to lower cholesterol levels in the blood. According to Drug Patent Watch [1], Lipitor is a statin drug that works by blocking an enzyme in the liver that produces cholesterol. On the other hand, antidepressants are medications used to treat depression and other mental health conditions. The effectiveness of antidepressants can be influenced by many factors, including drug interactions.

A study published in the Journal of Pharmacy Practice and Research [3] investigated the potential drug interaction between atorvastatin and antidepressants. The study found that atorvastatin does not significantly affect the pharmacokinetics of commonly used antidepressants. Therefore, the study concluded that atorvastatin is unlikely to affect the effectiveness of antidepressants.

Another study published in the Journal of Affective Disorders [2] investigated the effect of atorvastatin on depression symptoms in patients with coronary heart disease. The study found that atorvastatin treatment was associated with a significant reduction in depressive symptoms. Therefore, the study concluded that atorvastatin may have a beneficial effect on depression symptoms in patients with coronary heart disease.

In conclusion, based on the provided sources, there is no evidence to suggest that Lipitor (atorvastatin) affects the effectiveness of antidepressants. In fact, one study suggests that atorvastatin may have a beneficial effect on depression symptoms in patients with coronary heart disease. However, it is important to note that individual responses to medications can vary, and it is always recommended to consult with a healthcare provider before starting or stopping any medication.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/27468164/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827898/