Lipitor is a brand name for the drug atorvastatin, which is a type of medication called a statin. Statins are used to lower cholesterol levels in the blood, which can help reduce the risk of heart disease and stroke. According to the sources provided, there is no direct indication that low-fat substitutes should be avoided while taking Lipitor. However, it is important to understand how statins work and what foods may affect their effectiveness.

Statins work by blocking an enzyme in the liver that is responsible for producing cholesterol. This can lower the levels of LDL, or "bad" cholesterol, in the blood. However, statins can also lower levels of CoQ10, a nutrient that is important for heart health. Some studies have suggested that low levels of CoQ10 may be associated with muscle pain and weakness, which are common side effects of statins [2].

In terms of diet, it is generally recommended to follow a healthy and balanced diet while taking Lipitor. This may include reducing intake of saturated and trans fats, which can increase cholesterol levels in the blood. However, it is important to note that low-fat substitutes may not always be the healthiest option. Some low-fat foods may contain added sugars or other ingredients that can be harmful to health. It is important to read labels and choose whole foods whenever possible [3].

In summary, there is no direct indication that low-fat substitutes should be avoided while taking Lipitor. However, it is important to follow a healthy and balanced diet to support overall health and the effectiveness of the medication. This may include reducing intake of saturated and trans fats, but it is important to choose whole foods and read labels carefully [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.singlecare.com/blog/atorvastatin-alternatives/
[3] https://www.goodrx.com/atorvastatin/what-is