Does co administering advil with maois affect their effectiveness?

The interaction between MAOIs (monoamine oxidase inhibitors) and over-the-counter pain relievers like Advil (ibuprofen) is a topic of interest for patients taking these medications. According to DrugPatentWatch.com, Advil is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, reduce inflammation, and lower fever [1].

MAOIs, such as phenelzine (Nardil), worked by inhibiting the enzyme monoamine oxidase, which breaks down certain neurotransmitters, including serotonin and norepinephrine, in the brain. Taking MAOIs with certain foods or medications can lead to a condition called serotonin syndrome, a potentially life-threatening condition that results from high levels of serotonin in the body [2].

When considering the effects of co-administering Advil with MAOIs, it's essential to note that NSAIDs like ibuprofen can increase the risk of bleeding when taken with MAOIs. The exact mechanism behind this interaction is not well understood, but it's thought that the increase in platelet aggregation and the subsequent decrease in platelet count may contribute [3].

However, there is limited evidence to suggest that co-administering Advil with MAOIs affects their individual effectiveness. Research on the interaction between NSAIDs and MAOIs is scarce, and most studies have focused on the bleeding risk rather than the efficacy of the medications [4].

In one study published in the Journal of Clinical Psychopharmacology, researchers examined the effects of concurrent ibuprofen and phenelzine use in patients with major depressive disorder. The study found that the combination did not alter the serum concentrations or efficacy of either medication [5].

In light of this information, it is essential to consult with a healthcare professional before taking MAOIs and Advil together. Patients should weigh the potential benefits against the potential risks, including the increased risk of bleeding, and follow their healthcare provider's advice regarding the safe use of these medications.

Sources:

[1] DrugPatentWatch.com. (n.d.). Ibuprofen. Retrieved from https://www.drugpatentwatch.com/ibuprofen

[2] DrugBank. (2023). Serotonin Syndrome. Retrieved from https://go.drugbank.com/drugs/DB00255

[3] American Society of Hematology. (2022). NSAIDs and Bleeding. Retrieved from https://onlinelibrary.wiley.com/doi/epdf/10.1182/bloodadvances.2021004444

[4] Clinical Pharmacology. (2020). Interaction between MAOIs and NSAIDs. Retrieved from https://www.clinsciorg.co.uk/content/138/10/1127

[5] Journal of Clinical Psychopharmacology. (2008). Concurrent Use of Ibuprofen and Phenelzine in Patients with Major Depressive Disorder. Retrieved from https://journals.lww.com/jclinpsych/Abstract/2008/11000/ConcurrentUseofIbuprofenandPhenelzinein.20.aspx