Quetiapine is sold under the brand name Seroquel [1].
What is Seroquel used for?
Seroquel is prescribed to treat schizophrenia, bipolar disorder (manic and depressive episodes), and as an add-on treatment for major depressive disorder [2].
When does the Seroquel patent expire?
The primary patents for Seroquel have expired, allowing for the availability of generic versions [3]. The main composition of matter patent for quetiapine fumarate expired in 2011 [4].
Are there generic versions of Seroquel available?
Yes, generic quetiapine is available from multiple manufacturers [5]. This has led to increased competition and lower prices compared to the branded Seroquel [6].
How do generic quetiapine and brand-name Seroquel compare?
Generic quetiapine is bioequivalent to brand-name Seroquel, meaning it is absorbed into the bloodstream at the same rate and to the same extent [7]. This ensures that generic versions have the same therapeutic effect and safety profile as the original drug [8].
What are the risks and side effects associated with quetiapine?
Common side effects of quetiapine include drowsiness, dizziness, dry mouth, weight gain, constipation, and blurred vision [9]. More serious side effects can include movement disorders (tardive dyskinesia), high blood sugar and diabetes, increased cholesterol levels, low blood pressure, and an increased risk of stroke or death in elderly patients with dementia-related psychosis [10].
What is the mechanism of action for quetiapine?
Quetiapine is an atypical antipsychotic that works by affecting the activity of certain neurotransmitters in the brain, primarily dopamine and serotonin [11]. By balancing these chemicals, it helps to manage the symptoms of conditions like schizophrenia and bipolar disorder [12].
Who manufactures Seroquel?
Seroquel was originally developed and marketed by AstraZeneca [1]. Generic versions are produced by various pharmaceutical companies [5].
What should patients consider before taking quetiapine?
Patients should discuss their full medical history with their doctor, including any history of heart problems, diabetes, high cholesterol, or seizures [10]. It is also important to inform their doctor about all other medications they are taking, as quetiapine can interact with certain drugs [13].
Sources:
1. https://www.drugs.com/sfx/seroquel-side-effects.html
2. https://www.webmd.com/drugs/2/20292/quetiapine-oral/details
3. https://www.drugpatentwatch.com/
4. https://www.drugpatentwatch.com/search/quetiapine-fumarate/patents
5. https://www.healthline.com/health/quetiapine-oral-tablet
6. https://www.goodrx.com/quetiapine
7. https://www.rxlist.com/seroquel-drug.htm
8. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020677s049,021437s014,021848s013lbl.pdf
9. https://www.mayoclinic.org/drugs-supplements/quetiapine-oral-route/proper-use/drg-20067796
10. https://www.nhs.uk/medicines/quetiapine/
11. https://psychopharmacology.imedicalapps.com/drugs/quetiapine/mechanism-of-action
12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040921/
13. https://www.medicalnewstoday.com/articles/quetiapine-drug-interactions