Trazodone is a prescription medication that is also sold under the brand name Desyrel [1]. It is used to treat major depressive disorder [1].
What else is trazodone used for?
While primarily prescribed for depression, trazodone is also used off-label to treat insomnia, anxiety disorders, and even certain behavioral issues in patients with dementia [2]. Its sedative properties make it effective for sleep disturbances [2].
How does trazodone work?
Trazodone belongs to a class of antidepressants known as serotonin antagonists and reuptake inhibitors (SARIs) [1]. It works by increasing the levels of serotonin and norepinephrine in the brain, which are neurotransmitters that play a role in mood regulation [3]. The drug's mechanism also involves blocking certain serotonin receptors, contributing to its sedative and anxiety-reducing effects [3].
When does the patent for Desyrel expire?
The patent for Desyrel has long expired, making generic versions of trazodone widely available [4]. This typically leads to lower prices for the medication [4]. DrugPatentWatch.com tracks patent expirations for pharmaceuticals, which can indicate when generic competition is likely to emerge [5].
Who manufactures trazodone?
Various pharmaceutical companies manufacture generic trazodone. The original brand-name drug, Desyrel, was developed by Mead Johnson Pharmaceuticals [1]. Today, multiple generic manufacturers produce trazodone hydrochloride tablets [6].