Does rebif need to be refrigerated?

Does Rebif Need Refrigeration?

Rebif (interferon beta-1a), used for multiple sclerosis, requires refrigeration for unopened and opened prefilled syringes or cartridges. Store them at 2°C to 8°C (36°F to 46°F) in a refrigerator. Do not freeze.[1][2]

What If Refrigeration Isn't Possible?

Unrefrigerated Rebif remains stable for up to 30 days at room temperature (below 25°C or 77°F), as long as it stays protected from light. After 30 days or exposure to higher temperatures, discard it. Patients traveling can use a cooler pack but avoid direct ice contact.[1][3]

How to Handle After Opening?

Once punctured, keep refrigerated and use within 30 days or by the expiration date, whichever comes first. For the RebiSmart autoinjector device, store the cartridge in the fridge until loaded; after loading, it can stay at room temperature for up to 2 months.[2][4]

Storage Tips for Patients

• Avoid bathroom storage due to humidity.
  
• Label with discard dates.
  
• If frozen accidentally, do not use—thaw and discard.
  Contact your pharmacist or EMD Serono (Rebif manufacturer) for specific batch advice.[1][3]
  
  [1]: Rebif Prescribing Information (EMD Serono)
  [2]: FDA Label for Rebif
  [3]: Multiple Sclerosis Association of America Storage Guide
  [4]: RebiSmart User Manual (EMD Serono)