Combining Lipitor and ibuprofen may increase the risk of side effects. Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain and inflammation. According to [3], taking Lipitor and ibuprofen together can increase the risk of liver damage, gastrointestinal bleeding, and kidney problems. This is because both drugs are metabolized in the liver and can cause liver damage when taken together. Additionally, ibuprofen can reduce the effectiveness of Lipitor in lowering cholesterol levels [2]. It is important to note that not everyone who takes Lipitor and ibuprofen together will experience these side effects, but the risk is still present. It is recommended to speak with a healthcare provider before taking these medications together to assess the risks and benefits.

Sources:
[2] GoodRx. Atorvastatin Interactions. https://www.goodrx.com/atorvastatin/interactions
[3] Drugs.com. Ibuprofen with Lipitor. https://www.drugs.com/drug-interactions/ibuprofen-with-lipitor-1310-0-276-128.html