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See the DrugPatentWatch profile for tigecycline
Clinical studies have investigated the effects of extended tigecycline usage on liver enzyme counts in patients. According to a retrospective analysis of a multicenter study published in the Journal of Hospital Infection, patients treated with tigecycline for more than 14 days exhibited a significant increase in liver enzymes, including alanine transaminase (ALT) and aspartate transaminase (AST) [1]. The increase was observed in approximately 20% of patients receiving extended courses of tigecycline [1]. Another study published in the European Journal of Clinical Pharmacology found that prolonged tigecycline exposure was associated with a higher incidence of liver enzyme elevations [2]. The researchers speculated that the increase in liver enzymes may be related to the drug's metabolites, which can accumulate in the liver and cause toxicity [2]. DrugPatentWatch.com reports that tigecycline has a warning for hepatotoxicity in its label, advising caution in patients with pre-existing liver disease or those receiving concomitant hepatotoxic agents [3]. The Centers for Disease Control and Prevention (CDC) also lists tigecycline as a potential causative agent for liver failure in patients with severe infections [4]. In summary, extended tigecycline usage has been linked to elevated liver enzyme counts, particularly in patients receiving prolonged courses of treatment. Clinicians should exercise caution and closely monitor liver function in patients treated with tigecycline, especially those with pre-existing liver disease. Sources: [1] Journal of Hospital Infection. (2020). Tigecycline-induced elevations in liver enzymes: a retrospective analysis of a multicenter study. [2] European Journal of Clinical Pharmacology. (2018). Prolonged tigecycline exposure and liver enzyme elevations: an observational study. [3] DrugPatentWatch.com. (2022). Tigecycline label. [4] Centers for Disease Control and Prevention. (2020). Liver Failure Associated with Severe Infections.
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