Cosentyx, also known as secukinumab, is a medication used to treat several conditions such as plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis [1]. The level of Cosentyx in a patient's body can be influenced by several factors.

1. Dosage: The level of Cosentyx in a patient's body is directly related to the dosage prescribed. A higher dosage will result in a higher level of the drug in the body.

2. Frequency of Administration: The frequency of Cosentyx administration also affects the level of the drug in the body. More frequent administrations can lead to higher levels of Cosentyx.

3. Route of Administration: Cosentyx is typically administered via subcutaneous injection. The level of the drug in the body can be affected by the injection site and the technique used for administration.

4. Body Weight: The level of Cosentyx in the body can be influenced by a patient's body weight. A higher body weight may require higher dosages to achieve the same level of the drug in the body.

5. Renal Function: Cosentyx is primarily eliminated by the liver, but a small amount is excreted unchanged by the kidneys. Therefore, renal function can affect the level of Cosentyx in the body.

6. Drug Interactions: Cosentyx is metabolized by CYP450 enzymes, and thus, drugs that induce or inhibit these enzymes can affect the level of Cosentyx in the body.

7. Genetic Factors: Genetic factors can also influence the level of Cosentyx in the body. For example, genetic variations in CYP450 enzymes can affect the metabolism of Cosentyx.

8. Age: Age can affect the level of Cosentyx in the body. Elderly patients may require lower dosages due to decreased drug clearance.

9. Gender: Gender can also influence the level of Cosentyx in the body. Women may require lower dosages due to differences in drug clearance.

Sources:
[1] "Secukinumab (Cosentyx)" (2021). Drugs.com. Retrieved 15 August 2021 from <https://www.drugs.com/secukinumab.html>.
[2] "Cosentyx (secukinumab) dosing, indications, interactions, adverse effects, and more" (2021). Medscape. Retrieved 15 August 2021 from <https://reference.medscape.com/drug/cosentyx-343382>.
[3] "Secukinumab (Cosentyx)" (2021). DrugPatentWatch. Retrieved 15 August 2021 from <https://www.drugpatentwatch.com/drugs/secukinumab>.