Combining alcohol with certain medications or substances can lead to harmful interactions. When it comes to alcohol, it is important to be cautious, as it can interact negatively with various drugs. Alcohol can intensify the effects of some medications, leading to increased drowsiness, dizziness, or impaired coordination. It can also reduce the effectiveness of certain medications or even result in more severe side effects. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) warns that mixing alcohol with certain drugs can be dangerous and advises individuals to consult healthcare providers before combining alcohol with any medication. The Centers for Disease Control and Prevention (CDC) also highlight the risks associated with combining alcohol with other substances, such as caffeine. This combination can mask the depressant effects of alcohol, potentially leading to increased alcohol consumption and risky behaviors. It is crucial to be aware of these interactions and to seek medical advice if unsure about the potential risks of combining alcohol with other substances.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ALCOHOL
[2] https://www.niaaa.nih.gov/sites/default/files/publications/Harmful_Interactions.pdf
[3] https://www.cdc.gov/alcohol/fact-sheets/caffeine-and-alcohol.htm