Quetiapine fumarate is marketed under the brand name Seroquel [1][2]. It is also available in generic forms [1].
What is Seroquel used for?
Seroquel is prescribed to treat schizophrenia in adults and adolescents 13 years and older [3]. It is also used to manage manic or mixed episodes associated with bipolar I disorder in adults and children 10 years and older [3]. Additionally, Seroquel can be used as an add-on treatment for major depressive disorder in adults [3].
How does Seroquel work?
Seroquel, also known as quetiapine, is an atypical antipsychotic that works by affecting the balance of certain chemicals in the brain, specifically dopamine and serotonin [4]. By altering these neurotransmitter levels, it helps to manage symptoms of psychosis and mood disorders [4].
When did Seroquel's patent expire?
The original patent for Seroquel expired in 2011 [5]. This expiry allowed for the introduction of generic versions of quetiapine fumarate into the market [1][5].
Who makes Seroquel?
Seroquel was originally developed by AstraZeneca [2]. However, with the patent expiry, other pharmaceutical companies now manufacture and market generic versions of quetiapine fumarate [1].
What are the side effects of quetiapine fumarate?
Common side effects of quetiapine fumarate can include drowsiness, dizziness, dry mouth, weight gain, and constipation [4]. More serious side effects may include increased risk of stroke in elderly patients with dementia-related psychosis, tardive dyskinesia, and metabolic changes such as high blood sugar and cholesterol levels [4].
Can you switch from Seroquel to a generic?
Patients can typically switch from brand-name Seroquel to generic quetiapine fumarate. The decision to switch should be made in consultation with a healthcare provider, who can ensure the generic formulation is appropriate and monitor for any changes in effectiveness or side effects [3][4].
What is the difference between Seroquel and other antipsychotics?
Seroquel is classified as an atypical antipsychotic, which generally have a different side effect profile compared to older, typical antipsychotics. Atypical antipsychotics, including quetiapine, are thought to have a lower risk of movement-related side effects like tardive dyskinesia [4]. However, they may carry a higher risk of weight gain and metabolic issues [4].
What are the risks of taking quetiapine fumarate?
Quetiapine fumarate carries several risks, including an increased risk of death in elderly patients with dementia-related psychosis [3][4]. It can also cause serious side effects such as neuroleptic malignant syndrome, tardive dyskinesia, and significant metabolic changes like hyperglycemia and dyslipidemia [4]. Patients should be monitored regularly for these potential adverse effects [4].
What is the cost of quetiapine fumarate?
The cost of quetiapine fumarate can vary depending on whether it is a brand-name prescription or a generic version, as well as the pharmacy and insurance coverage [1]. Generic quetiapine fumarate is generally less expensive than brand-name Seroquel [1].
Sources:
[1] DrugPatentWatch.com
[2] https://www.drugs.com/sfx/seroquel-side-effects.html
[3] https://www.webmd.com/drugs/2/20436/quetiapine-oral
[4] https://www.mayoclinic.org/drugs-supplements/quetiapine-oral-route/proper-use/drg-20068156
[5] https://www.bloomberg.com/news/articles/2011-06-29/astrazeneca-loses-patent-protection-for-seroquel-in-u-s-rivals-ready-to-sell-generics