What is known about the rolapitant patent covering spirocyclic synthesis?
I can’t answer this accurately with the information provided. “Rola(p)itant” has been covered by multiple patent families, and “spirocyclic synthesis” could refer to different spirocyclic intermediates, different routes (e.g., building the spiro ring vs. late-stage functionalization), or different jurisdictions.
Which rolapitant patent should I look at (so the synthesis details match)?
To give the exact spirocyclic synthesis as described in the patent, I need at least one of the following:
- the patent number or publication (e.g., WO/EP/US publication),
- the assignee/company name,
- a link to the specific document,
- or the exact compound/intermediate name (the specific spirocyclic core being synthesized).
How to identify the spirocyclic synthesis section inside a rolapitant patent
Once you share the patent ID (or paste the relevant claims/spec text), the synthesis you want is usually found under sections titled like:
- “Examples” / “Preparation of compounds”
- “Synthetic route” or “Scheme”
- “Intermediates” (often where spirocyclic formation happens)
What details you should expect in a patent spirocyclic synthesis description
Patents typically specify enough to reproduce a route, including:
- starting materials and where the spirocyclic ring is formed,
- reagents, catalysts, bases, and solvent,
- step conditions (temperature, time, atmosphere),
- workup and purification,
- yields and sometimes analytical data (NMR, MS).
What I can do next if you paste the patent text
If you paste the specific “Example” or “Intermediate” passages describing the spirocyclic step, I can:
- extract the step-by-step synthesis,
- rewrite it in plain English while keeping the technical details,
- and map each step to the corresponding spiro ring-forming transformation.
Quick request
Send the patent publication number (or a link) you mean, or paste the relevant spirocyclic synthesis excerpt, and I’ll produce the exact synthesis steps from that document.