Lipitor is a medication used to lower cholesterol levels in the blood [1]. Avocados are a nutritious fruit that are commonly used in guacamole. There is no direct interaction between Lipitor and avocados in guacamole. However, it is important to note that certain foods can affect the absorption and effectiveness of Lipitor and other medications. According to a Tampa Bay Times article, grapefruit and grapefruit juice can interfere with the body's ability to metabolize certain medications, including Lipitor, which can lead to increased levels of the drug in the bloodstream and potentially harmful side effects [2]. Additionally, Stat News explains that high-fat meals can reduce the absorption of Lipitor, so it is recommended to take the medication on an empty stomach or with a low-fat meal [3]. Overall, while there is no direct interaction between Lipitor and avocados in guacamole, it is important to be mindful of potential food and drug interactions when taking medication.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.tampabay.com/archive/2010/01/27/food-and-drug-interactions/
[3] https://www.statnews.com/2016/11/03/medications-food-drug-interactions/