Can Simponi (golimumab) cause fatigue?
Yes. Fatigue can occur in people taking Simponi (golimumab). Fatigue is listed among possible side effects for Simponi, though it may not be common for everyone.
What kind of fatigue is it, and when should you contact a clinician?
If you feel unusually tired after starting Simponi, it’s worth letting your prescribing clinician know, especially if:
- fatigue is getting worse over time
- it’s severe enough to interfere with daily activities
- you also have symptoms like fever, infections, shortness of breath, or unexplained weakness (these can signal a problem that needs prompt evaluation)
Could fatigue be related to Simponi or to something else?
Fatigue in patients using Simponi can also come from the underlying inflammatory condition being treated (such as rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis), not only from the medication itself. Still, because Simponi can affect the immune system, new or worsening fatigue after treatment begins should be discussed with a healthcare professional.
Is fatigue different from serious side effects to watch for?
Fatigue is generally not the most alarming symptom, but it can overlap with more serious issues that need urgent care. Seek urgent help if fatigue comes with signs of serious infection (for example, fever, chills, or feeling very unwell), since Simponi can increase infection risk.
What should you do if you’re experiencing fatigue on Simponi?
Don’t stop Simponi on your own. Contact your clinician to review your symptoms and timing. They may check for infection, anemia, or other causes, and decide whether to adjust treatment.
Sources
- [1] https://www.drugs.com/simponi.html