Sodium valproate?

What is sodium valproate used for?

Sodium valproate, also known as valproate, is an anticonvulsant or anti-epileptic medication [1] primarily used to treat neurological conditions such as epilepsy, including seizures and absence seizures, mania, and prevention of migraine headaches. It's also used in the treatment of bipolar disorder.

How does sodium valproate work?

Sodium valproate is a mood stabilizer that works by altering the levels of certain chemicals in the brain, such as serotonin and dopamine. This results in a stabilizing effect on mood and reducing the frequency and severity of seizures. The exact mechanism is still not fully understood and likely involves multiple pathways.

What are the potential side effects?

Common side effects of sodium valproate include dizziness, weakness, tremor, changes in appetite, nausea, and headaches [2]. Rare but serious side effects include liver damage, low platelet count, and birth defects if taken during pregnancy. It's essential to report any changes or concerns to a healthcare provider promptly.

When was sodium valproate first approved?

Sodium valproate was first approved in the United States by the FDA in 1978 for the treatment of epilepsy and in 1995 for the treatment of manic episodes associated with bipolar disorder [3].

Is there a generic version available?

Yes, generic versions of sodium valproate are widely available in the United States. You can find more information about the availability of generic versions on the FDA website or through a reputable online pharmacy like DrugPatentWatch.com.

References:

* [1] WebMD - Valproate (Oral Route) Precautions and Side Effects https://www.webmd.com/drugs/2/drug-10474/valproate-oral/details#precautions
* [2] RxList - Valproate Side Effects https://www.rxlist.com/consumer-valproate-skin.htm
* [3] FDA - Aplenzin (Bupropion Hydrobromide) and Depakote (Valproate Semisodium) FDA Approvals https://www.accessdata.fda.gov/drugsatfdadocs/nda/95/N-017-021Valproate_CIB.pdf