Fenofibrate is available under several brand names, including Tricor, Antara, Lofibra, and TriCor [1][2].
What is fenofibrate used for?
Fenofibrate is a medication prescribed to manage high cholesterol and triglyceride levels. It is particularly used to reduce low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, and triglycerides, while increasing high-density lipoprotein (HDL) cholesterol [1]. This helps to lower the risk of cardiovascular events in certain patients [1].
How does fenofibrate work to lower cholesterol?
Fenofibrate belongs to a class of drugs called fibrates. It works by activating peroxisome proliferator-activated receptors (PPARs) in the liver [3]. This activation leads to a decrease in the production of triglycerides and an increase in the breakdown of LDL cholesterol, ultimately improving lipid profiles [3].
What is the difference between Tricor and Antara?
Both Tricor and Antara are brand names for fenofibrate. While they contain the same active ingredient, there can be differences in their formulation, dosage strengths, and how they are absorbed by the body, which may affect how they are prescribed and used [1][2].
When does fenofibrate patent protection expire?
The patent protection for fenofibrate has largely expired, allowing for the availability of generic versions [4]. DrugPatentWatch.com provides detailed information on patent expirations and exclusivity periods for pharmaceuticals.
Can I get generic fenofibrate instead of a brand name?
Yes, generic versions of fenofibrate are available and are typically prescribed as a more cost-effective alternative to brand-name medications like Tricor, Antara, Lofibra, and TriCor [4].
What are the common side effects of fenofibrate?
Common side effects associated with fenofibrate include gastrointestinal issues such as nausea, abdominal pain, and diarrhea. Other potential side effects may include back pain, headache, and elevated liver enzymes [1].
Are there any serious risks associated with taking fenofibrate?
Serious risks associated with fenofibrate can include muscle problems like myopathy and rhabdomyolysis, pancreatitis, liver dysfunction, and an increased risk of gallstones [1]. Patients are advised to report any unexplained muscle pain, tenderness, or weakness to their healthcare provider.
How does fenofibrate compare to other cholesterol-lowering drugs?
Fenofibrate is a fibrate, which works differently than statins, another common class of cholesterol-lowering drugs. Statins primarily inhibit cholesterol synthesis, while fibrates focus on reducing triglycerides and increasing HDL cholesterol [3]. Doctors may prescribe fenofibrate alone or in combination with other lipid-lowering agents, depending on a patient's specific lipid profile and cardiovascular risk factors [1].
Who manufactures brand-name fenofibrate products?
Abbott Laboratories markets Tricor in the United States [2]. Other manufacturers produce different brand-name formulations of fenofibrate.
Sources:
[1] https://www.mayoclinic.org/drugs-supplements/fenofibrate-oral-route/proper-use/drg-20073094
[2] https://www.drugs.com/mtm/fenofibrate.html
[3] https://www.ncbi.nlm.nih.gov/books/NBK532930/
[4] https://www.drugpatentwatch.com/